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plural antihistamines
(pharmacology) A drug or substance that counteracts the effects of a histamine. Commonly used to alleviate the symptoms of hay fever and other allergies. quotations
Perhaps the most striking method of demonstrating the effect of antihistamine substances is to use them to protect guinea-pigs against the action of histamine sprayed into the air from an atomizer.
1946 December, British journal of pharmacology and chemotherapy, volume 1, number 4, page 278