The frictions are made at bedtime, on a limited portion of the body, and on one side only—the calf of the leg by preference, or the thigh, groin, or axilla. It is enough to continue rubbing for from three to five minutes at most.
1874 January 7, M. Panas, “Treatment of Syphilis by Mercurial Friction”, in The London Medical Record, volume 1, page 5